Acquired inhibitors of blood coagulation, also known as circulating anticoagulants, can have serious clinical consequences or only be laboratory phenomena that have little clinical impact. These inhibitors are antibodies directed against one or more of the coagulation factors. Although inhibitors have been described against most of the coagulation factors, the two most common are discussed here. Factor VIII inhibitors are a type of "specific" inhibitor, directed only against factor VIII. The lupus anticoagulant is a "nonspecific" inhibitor that is directed against several of the coagulation factors.
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