Class IC Antidysrhythmic Agents

Encainide and flecainide are prototypical class IC agents. They have no effect on the duration of the action potential or the refractory period. They cause marked depression of automaticity (phase 4) of pacemaker cells and slow conduction velocity (phase 0). These agents are not used in the Ed setting because of associated prodysrhythmic effects. They were earlier thought helpful for the treatment of atrial fibrillation and refractory VT. However, the Cardiac Arrhythmia Suppression Trial (CAST) demonstrated an increased mortality associated with class IC agents when used to suppress ventricular ectopy in patients with a history of a recent MI and LV dysfunction.2 In fact, encainide was voluntarily taken off the market because of its prodysrhythmic tendencies. It is available only on a limited basis.

Was this article helpful?

0 0
How To Get Rid Of Bed Bugs

How To Get Rid Of Bed Bugs

If you seriously want know how to get rid of bed bugs, then this may be the most important letter you'll ever read!... Discover How To Solve Your Dilemma In What You Thought To Be Your Dream Vacation And Easily Taking The First Step To Conquer The Bed Bugs Trauma You May Have At This Moment! It doesn't matter, if you have never have any ideas on how to getting rid of bed bugs and how to banish it quickly in the shortest time possible, then this golden guides will show you everything steps you need to take against bed bugs banishing!

Get My Free Ebook

Post a comment