The clinical diagnosis of ALS is suggested when there are signs of both upper and lower motor neuron dysfunction without other CNS dysfunction. ALS-like symptoms can be seen with other systemic illnesses such as diabetes, dysproteinemia, thyroid dysfunction, vitamin B 12 deficiency, lead toxicity, and vasculitis, as well as CNS and spinal cord tumors. The diagnosis of ALS also requires that other inflammatory neuropathies such as myasthenia gravis be excluded. Established criteria for the diagnosis of ALS, the El Escorial criteria, have been developed by the World Federation of Neurology. 7
Electromyography (EMG) is the most useful diagnostic tool, showing decreased muscle action potential amplitude and decremental responses to repetitive nerve stimulation
Was this article helpful?
Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...