Myocarditis is broadly but nonspecifically defined as inflammation of the heart muscle and is most frequently characterized pathologically by focal infiltration of the myocardium by lymphocytes, plasma cells, and histiocytes. Varying amounts of myocytolysis and destruction of the interstitial reticulin network are also seen. 14 The pathologic changes have been ascribed to a number of infectious agents ( Table.. ..5.1-5), some of which involve the myocardium secondarily as part of a systemic disease process. Myocarditis is frequently accompanied by pericarditis.

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