Most patients seen in the ED due to adverse reactions from hallucinogen use can be discharged into the custody of family or friends if they are lucid and medically stable after a period of observation. Patients with persistent psychotic symptoms or other significant psychiatric disturbance may require psychiatric evaluation and possible hospital admission. Patients with significant medical complications of hallucinogen use, such as severe hypertension, hyperthermia, seizures, or rhabdomyolysis, should be admitted to the hospital for continued treatment and observation. All patients should be assessed for suicide wish.

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