Drug Interactions

Chronic MAOI drug therapy predisposes to many potentially significant drug interactions ( Table 154-1). However, documentation of human MAOI drug interactions is often limited to single case reports or case series.10 Controlled human studies are impractical due to the life-threatening nature of these reactions. Animal studies often have limited applicability to human toxicity. Most importantly, emergency physicians should never administer medications to patients taking MAOIs unless absolutely necessary. Drug compatibility with monoamine oxidase inhibitors should always be confirmed prior to drug administration.

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