Dyshemoglobinemias

Sean M. Rees Lewis S. Nelson

Methemoglobinemia Pathophysiology

Acquired Methemoglobinemia

Hereditary ā€˛Methemoglobinemia ciinic.al . . Features

Diagnosis

Treatment

Sulfhemoglobinemia chapter.. References

The dyshemoglobinemias are a constellation of disorders in which the hemoglobin molecule is structurally altered and prevented from carrying oxygen. The most clinically relevant dyshemoglobinemias are carboxyhemoglobin, methemoglobin, and sulfhemoglobin. Carboxyhemoglobin develops following carbon monoxide exposure and due to its unique importance and prevalence is discussed in Chap 198.. This section of the text reviews methemoglobinemia and sulfhemoglobinemia.

Although the exact prevalence of these disorders remains undefined, the American Association of Poison Control Centers database reports thousands of exposures to drugs and chemicals capable of producing methemoglobinemia, but unfortunately, cases in which methemoglobinemia actually occurred are not tallied. 1

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