The incidence of MG is less than 1 case per 100,000, and the prevalence is 10 to 15 per 100,000. 17 There are about 25,000 cases in the United States and 100 million cases worldwide. The most common age of onset for females is in the second and third decades. In males, the peak onset age is in the seventh and eighth decades. Although females were believed to have up to a 4-fold higher disease prevalence, with aging of the population, the higher prevalence has shifted to males. There is a slightly higher prevalence in the African-American population. Although family members of patients with MG are much more likely to develop MG, the disease is not transmitted by traditional Mendelian inheritance.
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