Ethylene glycol has many commercial uses as a coolant (antifreeze), preservative, and glycerine substitute; it has also been used in lacquers, cosmetics, polishes, and detergents. It may be ingested as an alcohol substitute by alcoholics, in suicide attempts, and accidentally by children. Ethylene glycol's toxicity is the result of the formation of two toxic metabolites, formaldehyde and formic acid. As with methanol, therapeutic strategies are based on prevention of formation of these metabolites or their removal from the body.
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