Exogenous Anticoagulants And Antiplatelet Agents

Stephen D. Emond John R. Cooke J. Stephan Stapczynski

Pathophysiology. oLThrombosis Agents

Oral, Anticoagulants Parenteral Anticoagulants

Blockers.. of ..Platelet Activation BiockersofPiatelei, ..Aggregation Fibrinolytic, Agents

Indications .forAntithrombotic. Therapy Acute.. Myocardia.! .Infarction

Deep. venous. .Xh,romb.osis..o,r .£ulm2nary..E.mboli.s,m


Cpmpljcationsof Anticoagulation .a.nd...Antithrom.boticM Therapy

Warfarin Heparin

Aspirin Fibrinolytics

Chapter References

Antithrombotic therapy is standard for numerous arterial and venous thromboembolic conditions, including acute myocardial infarction (AMI), unstable angina pectoris, deep venous thrombosis (DVT), pulmonary embolism (PE), and stroke or cerebrovascular accident (CVA). Moreover, antithrombotic agents help prevent occlusive vascular disease in patients at risk for thrombosis. These agents, however, also have the potential to cause life-threatening complications, primarily uncontrolled hemorrhage. This chapter provides an overview of antithrombotic agents, including mechanisms, indications, contraindications, and therapies, as well as evaluation and management of acute bleeding complications. Detailed management of thromboembolic disorders is discussed in their respective chapters.

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