Experimental Therapies

Many different therapies have been tried to decrease the toxic effects of caustic ingestions. Most experiential therapies have been aimed at preventing esophageal strictures after caustic alkali ingestion. Animal data have showed decreased stricture formation with drugs that affect collagen deposition, including b-aminopropionitrile, N-acetylcysteine, and D-penicillamine. Pentoxifylline, a local inflammatory and microcirculation mediator, has also been used experimentally. Oral agents to coat and protect the GI tract from insult, including sulcrafate, bismuth subsalicylate, and sodium polyacrylate, have been tried experimentally with some success. None of these agents have been evaluated in controlled clinical trials in humans, and more data are needed before a recommendation with respect to their use can be made.

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