Gastrointestinal Hepatic System

Perhaps the greatest morbidity from NSAID use is bleeding from the GI tract. At therapeutic doses, NSAIDs inhibition of cytoprotective gastric prostaglandins (PGI 2 and PGE2) increases the risk of gastric erosion, gastritis, and GI bleeding. There is a two- to fivefold increased risk of perforation or hemorrhage in NSAID users over the non-NSAID-using population. Data suggest that the risk for life-threatening bleeding is between 1.3 and 4 percent per year among NSAID users. It is estimated that NSAID-related GI bleeding contributes to 7500 deaths and 75,000 hospitalizations annually in the United States. The prostaglandin analogue misoprostol is effective at preventing NSAID-related gastric erosions at doses of 200 pg qid. Recently, the proton-pump inhibitor omeprazole has been shown to be effective at treating NSAID-related ulcers, but its role in prophylactic therapy is less clear. 7

Dieting Dilemma and Skinny Solutions

Dieting Dilemma and Skinny Solutions

The captivating thing about diets is that you don't get what is researched or predicted or calculated but rather, you get precisely what you expect. If the diet resonates with you then it will likely work, if it doesn't resonate, it won't.

Get My Free Ebook


Post a comment