Gestational Trophoblastic Disease

Gestational trophoblastic disease (GTD) is a disease of trophoblastic placental tissue. GTD represents a spectrum of diseases ranging from benign to frank malignancy.5 There are four forms of this process:

1. Hydatidiform mole

2. Invasive mole

3. Choriocarcinoma

4. Placental site tumors

The incidence of molar pregnancy is 1 in 2000 pregnancies; however, the incidence is much higher in Asian women, at 1 in 800. The risk of developing a second molar pregnancy is 1 to 3 percent, sometimes approaching 40 percent. Molar pregnancy is seen with a bimodal distribution. Persons younger than age 20 and older than age 40 are at greatest risk. GTD may be benign or malignant and, when malignant, can be divided into metastatic and nonmetastatic.

The benign form of this disease is hydatidiform mole, either partial or complete. This following summary table includes some of the major differences between partial and complete moles (T§ble..,10,7.-.1).

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