Glucocorticoid

Iherapy of primary adrenal insufficiency consists of replacement of cortisol and aldosterone, and, on occasion, supplemental androgen therapy in the female patient. Ihe usual maintenance dosage for glucocorticoid replacement varies from 20 to 37.5 mg of cortisol per day. Various preparations may be used (see I§b.!e 208-3 for steroid equivalents). A generally accepted dosage schedule is 5 mg of prednisone in the morning followed by 2.5 mg of prednisone in the afternoon. Ihis simulates the normal diurnal variation of cortisol secretion. A few patients, especially large active men, may require a total daily dose of 10 mg of prednisone for optimum response.

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