Iherapy of primary adrenal insufficiency consists of replacement of cortisol and aldosterone, and, on occasion, supplemental androgen therapy in the female patient. Ihe usual maintenance dosage for glucocorticoid replacement varies from 20 to 37.5 mg of cortisol per day. Various preparations may be used (see I§b.!e 208-3 for steroid equivalents). A generally accepted dosage schedule is 5 mg of prednisone in the morning followed by 2.5 mg of prednisone in the afternoon. Ihis simulates the normal diurnal variation of cortisol secretion. A few patients, especially large active men, may require a total daily dose of 10 mg of prednisone for optimum response.

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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