Idiopathic

Primary adrenal insufficiency, or Addison's disease, is due to disease or destruction of the adrenal cortex and has a wide variety of causes ( IabJ,e,,,,2..0.8.-..1..). Approximately 90 percent of the adrenal cortex must be involved before clinical manifestations of adrenal failure result. Idiopathic atrophy of the adrenal glands is the leading cause of chronic adrenal insufficiency. Idiopathic adrenal insufficiency has been further divided into autoimmune (70-75 percent) and truly idiopathic (25-30 percent).

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