Neonatal infections are manifested by a variety of symptoms and signs, such as feeding difficulties, fever, jaundice, and respiratory distress. Neck rigidity and Kernig and Brudzinski signs are usually absent in neonates with meningitis. A septic neonate may present with a normal or subnormal temperature. Urinary tract infections are often associated with nonspecific signs, such as irritability, diarrhea, or poor feeding, and diagnosis is established by urine culture rather than urinalysis. There is general consensus that all neonates with possible sepsis should be hospitalized and given broad-spectrum antibiotic therapy pending results of appropriate cultures (e.g., urine, blood, and cerebrospinal fluid). See " Feyerand.Sepsis" below.
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