Inpatient Therapy

(Note two drug therapy)

Erythromycin 10 mg/kg IV q6h (max 1 g/dose) [B, except estolate contraindicated] PLUS

Cefuroxime 50 mg/kg IV q8h (max 1 g/dose) [B] OUTPATIENT THERAPY

Note: Consider initiating outpatient therapy with a single dose of the parenteral antibiotics listed above for inpatient therapy.

1. Erythromycin 30-50 mg/kg/day PO divided qid Easy dose: 10 mg/kg/dose PO qid

Maximum: 250-500 mg/dose Liquids:

Erythromycin ethyl succinate (EES) 200 mg and 400 mg/5 mL [B]

Erythromycin estolate (Ilosone) 125 mg and 250 mg/5 mL (contraindicated in pregnancy)

2. Clarithromycin (Biaxin) 7.5 mg/kg/dose PO bid [C] Maximum: 250-500 mg/dose

Suspensions: 125 mg and 250 mg/5 mL

3. Erythromycin/sulfisoxazole (Pediazole) 50 mg/kg/day erythro and 150 mg/kg/day sulfa PO divided tid OR qid [C; D in 3rd trimester] Easy dose: 1.25 mL/kg/day PO divided qid

Maximum: 10 mL/dose

Suspension of erythromycin 200 mg and sulfisoxazole 600 mg/5 mL Course: 10-14 days

Organisms: S. pneumoniae, H. influenzae (1-24 months), Chlamydia pneumoniae, Mycoplasma pneumoniae, RSV (1-24 months), viral

C. ADULTS (60 YEARS OLD OR LESS, COMMUNITY ACQUIRED, NO COMORBIDITY)

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