Leukotriene Modifiers

Leukotrienes are potent proinflammatory mediators that contract airway smooth muscle, increase microvascular permeability, stimulate mucus secretion, decrease mucociliary clearance, and recruit eosinophils into the airway.1 Two leukotriene modifiers—zafirlukast and zileuton—are currently available as oral tablets for the treatment of asthma. Leukotriene modifiers improve lung function, diminish symptoms, and diminish the need for short-acting b 2 agonists. They are being investigated as an alternative to low-dose inhaled corticosteroid therapy and as steroid-sparing agents. There is currently no indication for the use of leukotriene modifiers in the treatment of acute bronchospasm.

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Dealing With Back Pain

Dealing With Back Pain

Deal With Your Pain, Lead A Wonderful Life An Live Like A 'Normal' Person. Before I really start telling you anything about me or finding out anything about you, I want you to know that I sympathize with you. Not only is it one of the most painful experiences to have backpain. Not only is it the number one excuse for employees not coming into work. But perhaps just as significantly, it is something that I suffered from for years.

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