Minoxidil is a direct-acting peripheral vasodilator that lowers systolic and diastolic blood pressure without much affect on the CNS. It also has the advantage of not interfering with vasomotor reflexes and therefore does not induce orthostatic hypotension.

Minoxidil, in tablet form, is usually reserved for the treatment of severe or refractory hypertension, and reported toxicity has been rare. A common side effect of minoxidil is hirsuitism. In 1988, a 2% topical solution of minoxidil was approved for the treatment of baldness. At least one case report exists involving ingestion of the topical solution. Regardless of the preparation, the most common symptoms of toxicity include hypotension and tachycardia. In patients with renal failure, fluid retention and pericardial effusion have been reported. Treatment is supportive and includes intravenous fluids. If the hypotension is persistent, dopamine or phenylephrine should be considered. Vasopressors with b-adrenergic activity, such as epinephrine, should be avoided because of the potential for excessive cardiac stimulation. b blockers can be used for symptomatic tachycardia.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

Get My Free Ebook

Post a comment