Mitral Valve Prolapse Pathophysiology

The etiology of mitral valve prolapse (MVP), or the click-murmur syndrome, is not known but may be congenital. MVP is the most common valvular heart disease in industrialized countries, affecting about 3 percent of the population. 3 One or both of the mitral valve leaflets prolapse into the atrium during systole, and this may or may not be accompanied by regurgitant flow. Male sex, age over 45, and the presence of regurgitation, recognized clinically by a short diastolic murmur, places the patient in a higher risk group for complications.4 Click-murmur syndrome has unique symptoms that differentiate it from other forms of mitral regurgitation.

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