Pathophysiology

The current theory is that wheezes are produced by airway flutter and vortex shedding from the central and distal airways, although movement of airway secretions may play a small role.9 While flutter and vortex shedding are possible in normal airways, these processes are more pronounced in obstructed airways. Airway obstruction is associated with the processes of bronchial smooth muscle contraction (bronchospasm), smooth muscle hypertrophy, increased mucus secretion, and peribronchial inflammation.

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