Pathophysiology

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Saez-Llorens X, McCracken GH Jr: Sepsis syndrome and septic shock in pediatrics: Current concepts of terminology, pathophysiology, and management. J Pediatr 123:497, 1993. Clinical Features

Bock HA: Pathophysiology of acute renal failure in septic shock: From prerenal to renal failure. Kidney Int 64(suppl):S15, 1998. Carleton SC: The cardiovascular effects of sepsis. Cardiol Clin 13:249, 1995.

Mammen EF: The haematological manifestations of sepsis. J Antimicrob Chemother 41(supp A):17, 1998. Parrillo JE: The cardiovascular pathophysiology of sepsis. Ann Rev Med 40:469, 1989.

Parrillo JE, Parker MM, Natanson C, et al: Septic shock in humans: Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy. Ann Intern Med 113:227, 1990. Snell RJ, Parrillo JE: Cardiovascular dysfunction in septic shock. Chest 99:1000, 1991.

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Abraham E, Wunderink R, Silverman H: Efficacy and safety of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. JAMA 273:934, 1995.

Cronin L, Cook DJ, Carlet J: Corticosteroid treatment for sepsis: A critical appraisal and meta-analysis of the literature. Crit Care Med 23:470, 1995.

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Task Force of the American College of Critical Care Medicine, Society of Critical Care Medicine: Practice parameters for hemodynamic support of sepsis in adult patients in sepsis. Crit Care Med 27(3):639-660, 1999.

Zeni F, Freeman B, Natanson C: Anti-inflammatory therapies to treat sepsis and septic shock: A reassessment. [editorial; comment] Crit Care Med 25:1095, 1997.

Ziegler EJ, Fisher CJ Jr, Sprung CL, et al: Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. N Engl J Med 324:429, 1991.

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