Pathophysiology

Rhabdomyolysis is a syndrome characterized by injury to skeletal muscle with subsequent release of intracellular contents. These contents include myoglobin, creatine phosphokinase (CPK), aldolase, lactate dehydrogenase (LDH), serum glutamic-oxaloacetic transaminase, and potassium. Although numerous causes of rhabdomyolysis have been described, the common terminal event appears to involve the disruption of the Na +,K+-ATPase pump and calcium transport, resulting in increased intracellular calcium and subsequent muscle cell necrosis.

Several classifications systems have been developed to characterize the numerous causes of rhabdomyolysis. None of these systems are universally recognized, and each has its own limitations. In addition, many patients have multiple causes of rhabdomyolysis (e.g., alcohol abuse and hypokalemia). TabJe,..2,71-1 lists the various causes. In general, the most common causes of rhabdomyolysis appear to be alcohol and drug abuse, toxin ingestion, trauma, infection, strenuous physical activity, and heat-related illness.

Was this article helpful?

0 0
Beat The Battle With The Bottle

Beat The Battle With The Bottle

Alcoholism is something that can't be formed in easy terms. Alcoholism as a whole refers to the circumstance whereby there's an obsession in man to keep ingesting beverages with alcohol content which is injurious to health. The circumstance of alcoholism doesn't let the person addicted have any command over ingestion despite being cognizant of the damaging consequences ensuing from it.

Get My Free Ebook


Post a comment