The toxic manifestations of these classes of medications include hypotension and bradycardia. Hypotension is best treated with intravenous fluids and, if necessary, vasopressors. If symptomatic bradycardia develops, atropine should be used. Seizures are a potential complication and should be treated with standard anticonvulsant therapy.
In addition to hypotension, a-adrenergic antagonists such as phentolamine may also cause CNS effects. No deaths have been attributed to the acute toxicity of phentolamine or to the ganglionic blocker trimethaphan. Other specific vasodilators are discussed below.
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