The use of sustained-release and second-generation dihydropyridine CCB preparations is now widespread. 1 These preparations provide a larger drug dose per tablet (especially in children), can extend the duration of clinical toxicity, and can lead to a delay in clinical manifestation of toxicity. Drawing from available case reports that provide plasma drug levels, several management guidelines can be asserted for overdose of any long-acting CCB preparation. First, if significant toxicity occurs, it will be manifested within 6 h of overdose7 although a 12-h delay in overt toxicity after a sustained-release verapamil overdose treated with charcoal administration has been reported.8 Peak drug levels and associated toxicity will occur within 12 h of overdose. Finally, chronic use of the drug will worsen and prolong toxicity of acute overdose.

51 Tips for Dealing with Endometriosis

51 Tips for Dealing with Endometriosis

Do you have Endometriosis? Do you think you do, but aren’t sure? Are you having a hard time learning to cope? 51 Tips for Dealing with Endometriosis can help.

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