Pharmacologic Properties

Drug absorption can occur after ingestion, smoking, or ocular use. The rate of absorption varies depending on the drug and the route of exposure. Because cholinergic blockade delays gastric emptying and decreases intestinal motility, absorption and peak clinical effects are often delayed. 2

The signs and symptoms of anticholinergic toxicity are a result of both central and peripheral cholinergic blockade. Muscarinic acetylcholine receptors predominate in the brain, while nicotinic receptors predominate in the spinal cord. Depending on the drug involved, antagonism of muscarinic, nicotinic, or both receptors may occur. 2 The central effects of cholinergic blockade include agitation, amnesia, anxiety, ataxia, coma, confusion, delirium, disorientation, dysarthria, hallucinations, hyperactivity, lethargy, somnolence, seizures, circulatory collapse, mydriasis, and respiratory failure. The peripheral effects include dysrhythmias, tachycardia, decreased bronchial secretions, dysphagia, decreased gastrointestinal motility, hyperthermia, hypo- or hypertension, decreased salivation, decreased sweating, urinary retention, and vasodilation.134

Reducing Blood Pressure Naturally

Reducing Blood Pressure Naturally

Do You Suffer From High Blood Pressure? Do You Feel Like This Silent Killer Might Be Stalking You? Have you been diagnosed or pre-hypertension and hypertension? Then JOIN THE CROWD Nearly 1 in 3 adults in the United States suffer from High Blood Pressure and only 1 in 3 adults are actually aware that they have it.

Get My Free Ebook


Post a comment