Plus

Rifampin (Rimactane) 10-20 mg/kg/day PO (max 600 mg/day) [C] PLUS

Pyrazinamide (PZA) 15-30 mg/kg/day PO (max 2 g/day) [C] PLUS

Ethambutol (Myambutol) 15-25 mg/kg/day PO (max 2.5 g/day) [B] OR

Streptomycin 20-40 mg/kg/day (max 1 g/day) [D] B. ADULTS

Isoniazid (INH) 5 mg/kg/day PO (max 300 mg/day) [C] PLUS

Rifampin (Rimactane) 10 mg/kg/day PO (max 600 mg/day) [C] PLUS

Pyrazinamide (PZA) 15-30 mg/kg/day PO (max 2 g/day) [C] PLUS

Ethambutol (Myambutol) 15-25 mg/kg/day PO (max 2.5 g/day) [B] OR

Course: Treatment regimens vary. Initiate therapy with all drugs simultaneously, and arrange appropriate follow-up. SEPSIS

Note: If patient condition permits, cultures should be obtained prior to antibiotic administration.

A. NEONATAL (UP TO 8 WEEKS OF AGE, NORMAL HOST) (Note two drug therapy)

Note: Ceftriaxone is no longer recommended in neonates due to the potential for biliary sludge pseudolithiasis. Cefotaxime (Claforan) 50 mg/kg IV/IM q8h (q12h if < 1 week old) [B] PLUS (to cover group B Strep and Listeria) Ampicillin 25 mg/kg IV/IM q6h (q8h if < 1 week old) [B]

Organisms: group B Strep, E. coli, Listeria, Klebsiella, Enterobacter, S. aureus, H. influenzae

B. INFANT/CHILD (NORMAL HOST)

1. Cefotaxime (Claforan) 50 mg/kg IV/IM q8h [B] OR

2. Ceftriaxone (Rocephin) 100 mg/kg IV or IM q24h [B]

Organisms: H. influenzae, S. pneumoniae, N. meningitidis, S. aureus

C. PEDIATRIC (IMMUNOCOMPROMISED) Regimen A

(Note two or three drug therapy) Ceftazidime (Fortaz) 50 mg/kg IV q8h [B] Mezlocillin (Mezlin) 50-75 mg/kg IV q 4-6 h [B] Ticarcillin (Ticar) 50 mg/kg IV q 4-6 h [B] Piperacillin (Pipracil) 50 mg/kg IV q 4-6 h [B] Ticarcillin/clavulanic acid (Timentin) 50 mg/kg IV q6h [B] Piperacillin/tazobactam (Zosyn) 100 mg/kg iV q8h [B] PLUS

Gentamicin (Garamycin) 2 mg/kg IV loading dose, then 1.7 mg/kg IV q8h (monitor serum levels) [D] OR Tobramycin (Nebcin) 2 mg/kg IV loading dose, then 1.7 mg/kg IV q8h (monitor serum levels) [D] OR Amikacin (Amikin) 5 mg/kg IV q8h (monitor serum levels) [D] PLUS/MINUS (if indwelling intravascular device present)

Vancomycin (Vancocin) 10 mg/kg IV q6h (max 1 g/dose; monitor serum levels) [C] Regimen B

(Note one or two drug therapy)

Imipenem (Primaxin) 30 mg/kg IV q8h [C] OR

Meropenem 40 mg/kg IV q8h [B]

PLUS/MINUS (if indwelling intravascular device present)

Vancomycin (Vancocin) 10 mg/kg IV q6h (max 1 g/dose; monitor serum levels) [C]

Organisms: Enterobacteriaceae, Pseudomonas sp., S. aureus, S. epidermidis, S. viridans, Corynebacterium sp.

D. PEDIATRIC PATIENTS WITH A SEVERE PENICILLIN ALLERGY

(Note two drug therapy)

Vancomycin (Vancocin) 10 mg/kg IV q6h (max 1 g/dose; monitor serum levels) [C] PLUS

1. Gentamicin (Garamycin) 2 mg/kg IV loading dose, then 1.7 mg/kg IV q8h (monitor serum levels) [D] OR

E. ADULT (NORMAL HOST) Regimen A

Ticarcillin/clavulanic acid (Timentin) 3.1 g IV q6h [B] Piperacillin/tazobactam (Zosyn) 3.375 g IV q6h [B] Imipenem (Primaxin) 500-1000 mg IV q8h [C] Meropenem 1 g IV q8h [B]

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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