Poliomyelitis is a neurotropic enterovirus that causes paralysis through motor neuron destruction and muscle denervation and atrophy. Despite the eradication of most polio cases through effective use of the polio vaccine in the United States, there are still cases that occur in children who are immunized and in populations that are not immunized. An important sequelae of acute poliomyelitis is postpolio syndrome, also termed postpoliomyelitis progressive muscular atrophy (PPMA). This disorder is characterized by the recurrence of motor symptoms following a latent period of several decades after the resolution of the motor symptoms caused by the initial infection.
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