Posttransplant Lymphoproliferative Disease PTLD

PTLD can be a consequence of T-cell suppression with long-term cyclosporine use. The overall incidence in lung transplant patients is approximately 8 percent. The disease tends to occur with primary EBV infection following lung transplant. Because younger patients are more likely to be EBV-negative at the time of transplantation, they tend to develop EBV infection and PTLD at a higher rate. Presenting features include isolated lymphadenopathy, painful otitis media (secondary to tonsillar involvement), or a viral-like syndrome. PTLD within 1 year of transplantation is usually localized and can be successfully treated with reduced immunosuppression and high-dose acyclovir, with a relatively good prognosis. In contrast, PTLD after 1 year tends to be disseminated, unresponsive to treatment, and usually fatal.

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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