Most patients with acute overdoses suffer little morbidity, but patients with significant overdoses may present with CNS, metabolic, hemodynamic, GI, or renal dysfunction.14 It is generally accepted that patients taking NSAIDs of the pyrazolone (phenylbutazone and oxyphenylbutazone) and the fenamic acid (mefenamic acid) families may present with the most severe clinical symptoms. It does not appear that NSAID metabolism is changed after acute overdose, and symptoms of acute overdose are usually apparent within 4 h of ingestion.
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