Regimen C

(Note two drug therapy) Ciprofloxacin (Cipro) 400 mg IV q12h [C] Ofloxacin (Floxin) 400 mg IV q12h [C] Levofloxacin (Levaquin) 500 mg IV qd [C] PLUS

Clindamycin (Cleocin) 900 mg IV q8h [B]

Organisms: gram positive cocci, gram negative cocci, anaerobes

F. ADULT (IMMUNOCOMPROMISED) Regimen A

(Note two or three drug therapy) Ceftazidime (Fortaz) 2 g IV q8h [B] Mezlocillin (Mezlin) 3 g IV q6h [B] Ticarcillin (Ticar) 3-4 g IV q4h [b] Piperacillin (Pipracil) 3-4 g IV q4h [B] Ticarcillin/clavulanic acid (Timentin) 3.1 g IV q6h [B] Piperacillin/tazobactam (Zosyn) 3.375 g IV q6h [B] PLUS

Gentamicin (Garamycin) 2 mg/kg IV loading dose, then 1.7 mg/kg IV q8h (monitor serum levels) [D] OR

Tobramycin (Nebcin) 2 mg/kg IV loading dose, then 1.7 mg/kg IV q8h (monitor serum levels) [D] OR

Amikacin (Amikin) 7.5 mg/kg IV q12h (monitor serum levels) [D] OR

PLUS/MINUS (if indwelling intravascular device present)

Vancomycin (Vancocin) 15 mg/kg IV q12h (max 1 g/dose; monitor serum levels) [C] Regimen B

(Note one or two drug therapy)

Imipenem (Primaxin) 500-1000 mg IV q8h [C] OR

Meropenem 1 g IV q8h [B]

PLUS/MINUS (if indwelling intravascular device present)

Vancomycin (Vancocin) 15 mg/kg IV q12h (max 1 g/dose; monitor serum levels) [C]

Organisms: Enterobacteriaceae, Pseudomonas, S. aureus, S. epidermidis, S. viridans, Corynebacterium sp.

G. ADULT PATIENTS WITH A SEVERE PENICILLIN ALLERGY

(Note two drug therapy)

1. Vancomycin (Vancocin) 15 mg/kg IV q12h (max 1 g/dose; monitor serum levels) [C] PLUS

1. Gentamicin (Garamycin) 2 mg/kg IV loading dose, then 1.7 mg/kg IV q8h (monitor serum levels) [D] OR

H. INTRAVENOUS DRUG ABUSERS

(Note two drug therapy)

OR (especially if catheter-induced sepsis)

2. Vancomycin (Vancocin) 15 mg/kg IV q12h (max 1 g/dose; monitor serum levels) [C] PLUS

1. Gentamicin (Garamycin) 2 mg/kg IV loading dose, then 1.7 mg/kg IV q8h (monitor serum levels) [D]

Organisms: S. aureus, Pseudomonas, enterococci

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