Renal and Metabolic Toxicity

Solvent abuse and occupational exposure to hydrocarbons may result in renal dysfunction. Exposure to hepatotoxic halogenated hydrocarbons, such as carbon tetrachloride and trichloroethylene, has caused acute renal failure as well as centrilobular hepatic necrosis. 15 Occupational hydrocarbon exposures have been associated with a variety of glomerulonephritides including Goodpasture's syndrome. —I8

Renal tubular acidosis may occur in patients who abuse toluene-containing substances. 1 Patients present with a non-anion gap metabolic acidosis, hypokalemia, and hypophosphatemia. The serum potassium may be so low (<2 meq/L) that severe muscle weakness develops, occasionally resulting in quadriparesis. Significant rhabdomyolysis may also result. Toluene toxicity may also cause a high anion gap metabolic acidosis as a result of the accumulation of hippuric acid and benzoic acid metabolites. Proteinuria and renal insufficiency can occur in patients who abuse toluene.

Was this article helpful?

0 0
Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

Get My Free Ebook


Post a comment