Rubella is characterized by all the following: (1) acute onset of generalized maculopapular rash, (2) temperature greater than 37.2°C (99°F), if measures, and (3) arthralgia/arthritis, lymphadenopathy, or conjunctivitis. Laboratory confirmation is obtained by (1) isolation of rubella virus, (2) significant rise in serum rubella IgG titers between the acute and convalescent phases by any standard serologic assay, or (3) positive serologic test for rubella IgM. It should be noted that rubella IgM tests are occasionally falsely positive in persons with other viral illnesses such as Epstein-Barr virus, cytomegalovirus, or parvovirus infection or in the presence of rheumatoid factor.

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