The use of prostaglandin synthase inhibitors, particularly indomethacin, has been found to be effective in delaying delivery by 48 h, but there have been increased rates of neonatal morbidity, with complications including closure of the ductus arteriosus, necrotizing enterocolitis, and intracranial hemorrhage. Recommendations for routine use of this agent for tocolysis must await further investigations.
Since preterm infants are at increased risk of developing group B streptococcus infection and there is reason to suspect that the infection may cause preterm labor, 5 million units of penicillin G is given intravenously unless the patient is allergic to it. 16
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