TABLE 1551 Pharmacologic Classification of Typical and Atypical Antipsychotic Agents

Conventional, or typical, antipsychotics are a diverse group of older agents that gained widespread acceptance for the control of the positive symptoms (e.g., hallucinations, delusions, and disordered thought) of schizophrenia and related psychoses. These agents cause numerous adverse effects, however, and do little if anything to ameliorate the cognitive dysfunction and negative symptoms (e.g., withdrawal, flat affect, and loss of drive) that are also characteristic of the disease. Thus, a newer class of atypical antipsychotic drugs has emerged, featuring improved clinical efficacy and a different side-effect and toxicologic profile. 1

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