TABLE 2127 Products Used for Replacement Therapy in Patients with Hemophilia B

Fkiot (uril*) = kg x adivity desired - % itilriniic aaiviiy)

If it is necessary to raise the factor IX level to 75 to 100 percent (e.g., life-threatening situations), this should be done with the highly purified concentrates because they carry essentially no risk of thrombogenicity. In settings where factor IX concentrates are not available, FFP can be used to raise the factor IX level. The use of FFP in this setting should be limited to emergency treatment because of the small risk of viral transmission and the inability to raise the factor IX levels adequately because of volume constraints. One unit of FFP will raise the factor IX level by 3 percent in an average-sized person.

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