Treatment Once the diagnosis of MOE has been made, the patient must be admitted to the hospital for parenteral antibiotics. Therapy with an aminoglycoside and antipseudomonal penicillin, or cephalosporin, or quinolone is standard, and should be initiated in the emergency department. Selected cases may be managed with oral quinolones, depending on the otolaryngologist's preference.
The ultimate prognosis of MOE is primarily based on the stage of disease at presentation. Earlier stages are likely to completely resolve with a single course of antibiotic therapy, while more advanced stages may require surgical debridement and may ultimately prove fatal.
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