TABLE 521 Predisposing Factors for Thromboembolic Disease

The pathophysiologic effects of PE are caused both by mechanical obstruction of the pulmonary arterial system and by the release of vaso- and bronchoactive mediators. Mechanical obstruction produces the clinical picture of acute cor pulmonale. The trigger for the release of chemical mediators is platelet degranulation in the lung. These mediators—prostaglandins, catecholamines, serotonin, and histamine—cause bronchoconstriction as well as pulmonary artery vasoconstriction. This results in an overall reduction in lung compliance. Vasoconstriction is the predominant effect, leading to a ventilation/perfusion ( ) mismatch. Vasoconstriction may be severe enough to cause pulmonary hemorrhage or infarct, producing an infiltrate on the chest radiograph. The infiltrate of pulmonary hemorrhage usually resolves in 1 to 2 weeks, while that of infarct may take months to disappear.5

PE tend to be multiple and bilateral, with the right lower lobe of the lung being the most commonly involved lung segment. Angiographic evidence of PE generally resolves in 1 to 4 weeks and pulmonary artery (PA) pressure usually normalizes within a month. If the PE fails to resolve, chronic cor pulmonale may occur.

Was this article helpful?

0 0
Spiritual Weight Loss Mentality

Spiritual Weight Loss Mentality

Awesome Ways To Get Over Your Mentality That Keeps you Overweight! This Book Is One Of The Most Valuable Resources In The World When It Comes To Results In Your Slim-down and Health Efforts! Day in day out we keep ourselves absorbed with those matters that matter the most to us. A lot of times, it might be just to survive and bring in some money. In doing so we at times disregard or forget about the extra matters that are essential to balance our lives. They’re even more essential to supply real meaning to our world. You have to pay attention to your wellness.

Get My Free Ebook

Post a comment