Topiramate (Topamax) became available in 1997. Its mechanism of action is uncertain, but it appears to be effective in preventing propagation of the seizure from its focus. The half-life is 19 to 23 h, and 85 percent of the drug is eliminated unchanged through the renal system. The remaining 15 percent is metabolized by P-450 hepatic metabolism. With the relatively long half-life, the drug is given in a twice-daily dosage. It is indicated in the treatment of partial seizures and is being evaluated as monotherapy. In children, the drug is begun slowly at 1 mg/kg/day and over 8 to 12 weeks is gradually increased to a maximum of 10 mg/kg/day or 400 mg/day if necessary. The major side effect limiting dosage and rate of incrementing dosage is the effect on memory and name recall.

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

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