Toxicophysiology

Excessive b-receptor blockade predictably decreases inotropy, chronotropy, and metabolic effects that are expected from subunit stimulation, resulting in hallmark bradycardia and hypotension.

Other mechanisms may contribute to b-blocker toxicity. Several b-blocker drugs antagonize myocardial sodium channels (IabJe...169-1) in a manner similar to the effects of quinidine or cyclic antidepressants. Impedance of sodium entry slows phase zero of the action potential, resulting in prolonged QRS duration and myocardial depression. Thus, patients may present with wide-complex bradycardia.

Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

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