There is no specific treatment for patients who develop renal failure from Cortinarius or Amanita smithiana. Urine output and electrolyte, calcium, magnesium, blood urea nitrogen, and creatinine levels should be monitored. Hemodialysis support is indicated for refractory hyperkalemia, refractory acidosis, uremic symptoms, or severe renal dysfunction. As spontaneous improvement is reported, renal transplant should be withheld for several months to monitor patient response. Renal transplant has been used in several patients with good success.

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