The treatment of impetigo is oral antibiotic therapy or an appropriate topical antibiotic for limited eruptions. A first generation oral cephalosporin such as cephalexin (50 mg/kg/day) or erythromycin (50 mg/kg/day) provides effective oral therapy. Mupirocin is the only topical agent with proven efficacy. 3 Combination topical and systemic therapy is unnecessary. Vigorous scrubbing, in addition to topical or systemic antibiotic agents, offers no advantage; routine cleanliness is sufficient.
Antibiotic therapy hastens the resolution of impetigo and limits suppurative complications. Although the incidence of glomerulonephritis may be reduced, it has not been possible to demonstrate this effect with certainty in clinical studies due to the low incidence of this disease.
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