• May take on empty stomach or with meals.
• May cause rash, nausea, or vomiting.
• May cause acute hemolytic anemia in patients with G6PD deficiency.
• Blood dyscrasias (e.g., thrombocytopenia, megaloblastic anemia, neutropenia) are dose-related.
• TMP/SMX is pregnancy category C in trimesters 1 and 2, and category D in 3rd trimester. Trimethoprim interferes with folic acid metabolism and therefore should be used in the 1st and 2nd trimesters only if the potential benefit outweighs the potential risk. TMP/SMX is contraindicated in the 3rd trimester because it can cause kernicterus.
• Increases phenytoin levels.
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