Vasodilator Agents

NITROGLYCERIN Actions Although the mechanism of action of nitroglycerin is not fully understood, its therapeutic benefit appears to be due to its actions on the peripheral circulation and the coronary blood flow. Nitroglycerin is a direct vasodilator that induces venodilation at low doses (<100 mg/min) and arteriolar vasodilation at high doses (>200 mg/min). Coronary artery dilation occurs throughout the dosage range.

Pharmacokinetics Iable25:6 describes the onset and duration of action of various nitroglycerin products. Nitroglycerin has a plasma half-life of 1 to 4 min and is metabolized in the liver. Oral doses undergo an extensive first-pass metabolism.

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