Warfarin and NSAIDs have important interactions. Two NSAIDs (phenylbutazone and naproxen) have been reported to displace warfarin from plasma proteins, leading to increased warfarin levels in serum and elevated prothrombin times. Phenylbutazone has also been shown to decrease elimination of warfarin. Other NSAIDs have not been reported to change warfarin protein binding or elimination, but the use of any NSAID is contraindicated in warfarin users because NSAID inhibition of platelet aggregation may significantly increase the risk for bleeding.
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.