Bioreactor Design

The purpose of the fermentor is to provide an aseptic environment in which fermentation can be performed efficiently to achieve process targets. The reliable operation of a fermentation system to achieve process objectives depends on two factors: the fermentor design and the fermentation process. Therefore, rational design of a fermentor requires careful consideration of how it is integrated into the process design. The design should consider from the outset such factors as plant scheduling, space constraints, relationships between fermentor productivity and throughput rates of downstream equipment, containment and validation requirements, utilities requirements, potential interruptions in normal plant operation, overall labor requirements and operating versus capital costs. Consistency, safety, cost, and compliance with statutory requirements usually are of prime concern for production equipment.

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