Complexation occurs with many acid radicals, notably chlorogenate, salicylate, citrate, benzoate, and cinnamate. Chlorogenic acid forms a tightly bound 1:1 complex. It is soluble in chloroform and can be recrystallized from aqueous alcohol, attesting to its stability. In plant matter much of the caffeine exists in this form (4). Complexes with phenolic molecules are only stable below pH 6. Caffeine is a weak base; its acid salts hydrolyze readily. It is converted
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If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.