Highpotency Nonnutritive Sweeteners Of Major Commercial Significance

The four nonnutritive sweeteners saccharin, cyclamate, aspartame, and acesulfame-K are used extensively today. In addition, sucralose and alitame are newcomers that may see significant use in the future. These six sweeteners are discussed in detail in this section. These sweeteners are approved for general use in the United States except for alitame. The chemical composition, a history of discovery and development, and discussions of taste quality, safety, solubility, and stability issues are presented for each.


Saccharin (1) is the first sweet-tasting organic compound identified that is significantly more potent than sucrose. It was discovered in 1878 by Fahlberg while he was working in the Remsen's laboratory at Johns Hopkins University (2). Saccharin is exemplary of the iV-sulfonyl amide structural class of sweeteners that is distinguished by the common -C0NHS02- substructural unit.

Appetite Antidote

Appetite Antidote

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