Many agencies and regulations impact the feeding of livestock and the manufacture of feeds, including state feed regulations, the FDA, the Environmental Protection Agency, and the Occupational Safety and Health Agency (19,38,39). In 1909, AAFCO was organized; its objective is "... to promote uniformity in legislation, definitions, and rulings, and the enforcement of laws relating to the manufacture, sale, and distribution of feeds and livestock remedies in the continent of North America." Good Manufacturing Practice Regulations for Medicated Feeds (30) were published by the FDA in 1976 and revised in 1986.

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