The physiological effects of caffeine become greatly intensified at high dosages. Caffeine affects the cortex, the medulla, and eventually the spinal cord as dosages are increased (28). The LD50 of caffeine is similar for many mammals—about 200 mg/kg (42). This would suggest an LD50 of about 3.5 g for humans based on normal metabolic weight corrections. It is more generally accepted that the lethal oral dose is about 10 g. Lethal plasma concentration is in the range of 0.5 to 1.0 mM. To achieve this concentration would require the consumption of about 75 cups of coffee over a very short period of time (40). Lethality resulting from beverage consumption is most unlikely. The few recorded cases of death from caffeine consumption have involved the pure substance or medications containing it.

The Mediterranean Diet Meltdown

The Mediterranean Diet Meltdown

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